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Augmented antidepressants
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From research out of
Combination antidepressants to better support you
Lucin is an augmented combination medication that acts at two points in the serotonin pathway: enhancing serotonin synthesis and inhibiting its reuptake.
Introducin the Lucin medication class
From research out of
Prescription required.
Sertralucin
SERTRALINE (active ingredient of Zoloft®) and L-METHYLFOLATE CALCIUM (active ingredient of Deplin FC®)
Citalucin
CITALOPRAM (active ingredient of Celexa®) and L-METHYLFOLATE CALCIUM (active ingredient of Deplin FC®)
Fluoxelucin
FLUOXETINE (active ingredient of Prozac®) and L-METHYLFOLATE CALCIUM (active ingredient of Deplin FC®)
Escilucin
ESCITALOPRAM (active ingredient of Lexapro®) and L-METHYLFOLATE CALCIUM (active ingredient of Deplin FC®)
What the research shows
Shown to reduce symptoms up to 84%
Compared to SSRI monotherapy, adjunctive prescriptive L-methylfolate reduced depressive symptoms by up to 84%.1
No additional SSRI specific side effects
Adjunct L-methylfolate in clinical trials was comparable to placebo (sugar pill) in tolerability and side effect portfolio.2
Recommended by the world’s most widely-used psychiatric guidelines
CANMAT and CARLAT Psychiatry report3,4 recommend prescriptive l-methylfolate augmentation to SSRI treatment.
1 .Papakostas G, et al. Am J Psychiatry. 2012;169:1267-1274.
2. Zajecka JM, et al. Journal of Clinical Psychiatry. 2016;77(5):654-660.
3. Sarris J, et al. World J BIol Psychiatry. 2022; 424-455
4. Carlat Report. https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/5361-folate-and-depression
Frequently Asked
Questions
What is a combination medication?
A combination medication is a single medication containing two or more active ingredients that have mechanistic complementarity. A common example you may be familiar with is Bactrim (Trimethoprim-sulfamethoxazole).
Escalucin, Fluoxlucin, Sertralucin, and Citalucin are combination antidepressant medications that are complexed with prescriptive L-methylfolate, which increases monoamine neurotransmitter synthesis while the SSRI blocks it's reuptake. Learn more here.
Do I need a prescription?
How do I get my medication?
Medications are shipped directly to your doorstep via 2-day shipping. You will be charged only once we receive a prescription from your provider. Refills will be automatically processed (we will give you a 24 hour notice before, which you can cancel any time) to ensure you get your medication without delay.
I am a provider. How do I prescribe?
Escalucin, Fluoxlucin, Sertralucin, and Citalucin can be prescribed from any EHR to our partner pharmacy, Valiant Pharmacy. Check out instructions for how to prescribe SSRI+ here.
What states is SSRI+ available in?
Currently, Escalucin, Fluoxlucin, Sertralucin, and Citalucin is available in all states excluding Arkansas and Alabama.
How do I start?
Click here to start. Depending on whether you already have a prescriber for mental health medications, or you would like one, we can help direct you to the right place.
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